GUEST SEMINARS: Erasmus+
Faculty of Chemistry, Ingardena 3
Jagiellonian University in Krakow
 

MONDAY, 4.04.2016
LECTURE ROOM 15, 9:30
Assoc. Prof. Přemysl Mladěnka, PharmD., Ph.D.
Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmacology and Toxicology, Czech Republic

An invitation for studying at the Faculty of Pharmacy in Hradec Králové, Charles University Introduction of the Faculty of Pharmacy in Hradec Králové

• Introduction of the Faculty of Pharmacy in Hradec Králové
• Studying possibilities (ERASMUS+ program, doctoral study)
• List of research groups and their topics available for ERASMUS+ students (research project and/or elaboration of diploma theses)

Flavonoids as a potential source of novel cardiovascular drugs
Flavonoids are a large group of compounds with many suggested cardiovascular effects. However, although many epidemiological studies found a relationship between intake of flavonoids and cardiovascular diseases, clinical evidence of positive cardiovascular effects of flavonoids is sparse. Moreover, structural diversity of flavonoids and their complex metabolism seem to be important determinants for their effects. This lecture will summarize the possible mechanisms of action of flavonoids relevant to the cardiovascular system (in particular interaction with transition metals iron and copper with following antioxidant or prooxidant effect, inhibition of reactive oxygen species forming enzymes, direct vasodilatory potential, antiplatelet effects). Emphasis will be given on the structure/activity relationship and possible clinical relevance.

MONDAY, 4.04.2016
LECTURE ROOM 115, 16:15
Assoc. Prof. Přemysl Mladěnka, PharmD., Ph.D.
Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmacology and Toxicology, Czech Republic

QT-prolongation, a serious adverse effect of several drugs
QT-prolongation could be a serious adverse effect of many drugs with potentially fatal outcome. Many drugs have been withdrawn from the market (e.g. antihistamines terfenadine and astemizole, prokinetic cisapride) due to this reason. The molecular base for QT-prolongation is the attenuation of IKr-current caused in majority cases by direct blockade of so called hERG-channel in the heart.
This lecture is intended for broader audience and hence, firstly physiological aspects of action potential conduction in the heart we be discussed followed by explanation of mechanism of QT-prolongation, its consequences, risk assessment and treatment. This lecture was prepared by support of Learning Toxicology Through Open Educational Resources project (TOX-OER, No. 2015-1-ES01-KA203-015957) and will serve as an invitation for participation on the project.

WEDNESDAY, 6.04.2016
LECTURE ROOM 30, 9:45
Assoc. Prof. Přemysl Mladěnka, PharmD., Ph.D.
Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmacology and Toxicology, Czech Republic

Meeting with Guest: discussions, exchange of experience.